Alteration of apical-basal polarity regulating proteins Par/Lgl/Scrib in lung adenocarcinomas and its relationship with invasion and metastasis

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Epithelial cells have an apical surface facing a lumen and a basal surface facing extracellular matrix. Abnormality of apical-basal polarity in neoplastic change was examined in the aspect of localization of invadopodia proteins in lung adenocarcinomas. Actinin-1 and cortactin showed matrix-contact-side localization in adenocarcinoma cells, but rarely in normal bronchiolar epithelial cells, alveolar cells, or precursor neoplastic lesions. Matrix-contact-side localization of invadopodia-related proteins could be histological markers indicative for invasion, metastasis, and poor prognosis. Rho guanine exchange factor/Ect2, one of Par6-binding proteins, was a possible regulator of polarity abnormality in lung adenocarcinomas.