Clinicopathological significance of α-Dystroglycan glycosylation in prostate cancer

我们检测了α-糖醛酸失调聚糖（α-DG）糖基化在人前列腺癌中的意义。在前列腺癌细胞中，我们发现α-DG糖基化水平的降低比α-DG核心蛋白水平的降低更为明显。根据Gleason分级系统评估，这种变化与癌的高度浸润性组织学模式有关。我们还发现α-DG上的层粘连蛋白结合聚糖在基底细胞的基底侧表达，并且这些聚糖在非肿瘤性前列腺组织的基底膜上与层粘连蛋白共定位。这种关联在前列腺癌中不存在。

We examined the significance of α-dystroglycan (α-DG) glycosylation in human prostate carcinoma. In prostate carcinoma cells, we found that the reduction in the level of α-DG glycosylation was more conspicuous than reduced level of α-DG core protein. This change was associated with highly infiltrative histological patterns of the carcinoma, as assessed by Gleason grading system. We also found that laminin-binding glycans on α-DG was expressed on the basal side of basal cells, and that these glycans colocalized with laminin in the basement membrane in non-neoplastic prostate tissue. This association was absent in prostate adenocarcinoma.