Clinicopathological significance of α-Dystroglycan glycosylation in prostate cancer

α-肌营养不良聚糖糖基化在前列腺癌中的临床病理意义

• 批准号: 22590311
• 负责人: SHIMOJO Hisashi
• 金额: $ 2.33万
• 依托单位: Shinshu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590311/
• 关键词: 泌尿生殖器; 癌; 糖鎖; 前立腺癌

We examined the significance of α-dystroglycan (α-DG) glycosylation in human prostate carcinoma. In prostate carcinoma cells, we found that the reduction in the level of α-DG glycosylation was more conspicuous than reduced level of α-DG core protein. This change was associated with highly infiltrative histological patterns of the carcinoma, as assessed by Gleason grading system. We also found that laminin-binding glycans on α-DG was expressed on the basal side of basal cells, and that these glycans colocalized with laminin in the basement membrane in non-neoplastic prostate tissue. This association was absent in prostate adenocarcinoma.

我们研究了α-肌营养不良蛋白聚糖（α-DG）糖基化在人前列腺癌中的意义。在前列腺癌细胞中，我们发现α-DG糖基化水平的降低比α-DG核心蛋白水平的降低更明显。根据Gleason分级系统评估，这种变化与癌的高度浸润性组织学模式相关。我们还发现α-DG上的层粘连蛋白结合聚糖在基底细胞的基底侧表达，并且这些聚糖与非肿瘤性前列腺组织中的基底膜中的层粘连蛋白共定位。前列腺腺癌中不存在这种相关性。

项目成果

Reduced glycosylation of α-dystroglycans on carcinoma cells contributes to formation of highly infiltrative histological patterns in prostate cancer.

• DOI: 10.1002/pros.21330
• 发表时间: 2011-08-01
• 期刊: PROSTATE
• 影响因子: 2.8
• 作者: Shimojo, Hisashi;Kobayashi, Motohiro;Kamigaito, Takayuki;Shimojo, Yasuyo;Fukuda, Minoru;Nakayama, Jun
• 通讯作者: Nakayama, Jun

Reduced Glycosylation of a-Dystroglycans on Carcinoma Cells Contributes to Formation of Highly Infiltrative Histological Patterns in Prostate Cancer

癌细胞上α-肌营养不良聚糖糖基化的减少有助于前列腺癌中高度浸润组织学模式的形成

• 发表时间: 2010
• 作者: Takano K;Yamashita S;Takemoto K;Inoue T;Sakata N;Kuwabara Y;Yonemitsu K;島崎都;下条久志
• 通讯作者: 下条久志

前立腺癌におけるα-ジストログリカン糖鎖と浸潤性増殖パターンとの関連

α-肌营养不良聚糖糖链与前列腺癌侵袭性生长模式的关系

• 发表时间: 2011
• 作者: 下条久志;小林基弘;中山淳
• 通讯作者: 中山淳