Aberrant microRNA expression and itsfunctional roles insofttissue sarcoma

我们对滑膜肉瘤（一种代表性的人类肉瘤）中miRNA的全球表达分析表明，包括let-7 e和miR-99 b在内的几种miRNA过表达，它们聚集在同一染色体位点。这些miRNAs的敲低导致细胞增殖减少，这首次表明过表达的此类miRNAs可能通过下调其分子靶点（如已知为潜在肿瘤抑制因子的HMGA 2和SMARCA 5）诱导肉瘤发生。

Our global expression analysis of miRNA in synovial sarcoma, a representative human sarcoma, demonstrated overexpression of several miRNAs including let-7e and miR-99b, which are clustered in the same chromosomal locus. Knock down of these miRNAs resulted in reduced cell proliferation, suggesting for the first time that overexpressed such miRNAs may induce sarcomagenesis through down-regulation of their molecular targets such as HMGA2 and SMARCA5 that are known as potential tumor suppressors.