Establish of mutant S19 ribosomal protein dimer functional deficient mice

与野生型小鼠相比,骨髓细胞、脾细胞,peripheralerythrocytes略但在RP S19显著降低低聚物functionaldeficient敲入小鼠。此外，基于FACS分析中CD71/TER119的表达值，敲入小鼠中嗜碱性红细胞的比例也有所下降。在血凝素诱导的溶血性贫血中测定红细胞的恢复时间时，敲入小鼠可延长红细胞的恢复时间。现在，我们开始检查RP s19寡聚物是否与DBA有关。之后，我们将通过RP S19寡聚物依赖的红母细胞岛形成来提出红细胞的维持系统。

In contrast to wild-type mice, numbers of bone marrow cells, spleen cells, and peripheralerythrocytes were slightly but significantly decreased in RP S19 oligomer functionaldeficient (Knock-In) mice. Moreover, a ratio of basophilic erythroblasts in Knock-In micewas also decreased based on the CD71/TER119 expression values in FACS analysis. When arecovering time of erythrocytes is measured in hemagglutinin-induced hemolytic anemiamice, the time was extended by Knock-In mice. Now, we start to examine whether RP S19oligomers are contributed with DBA. After that, we are to propose a maintenance systemof erythrocytes via RP S19 oligomer-dependent erythroblast island formation.