Proteomic analyses of Ascaris mitochondrial respiratory chain

目的：本研究旨在通过分析蠕虫蛋白，特别是线粒体蛋白对氧分压变化的反应，来阐明感染的建立和维持的潜在机制。取得的成果：目前的研究表明：1)猪蛔虫成虫特有的细胞色素b5在寄生适应中起着关键作用。2)卫氏并殖吸虫在不同组织中具有有氧和无氧线粒体，以适应微氧生境中不断变化的氧分压。

Objectives:This research project was undertaken to elucidate underlying mechanisms for the establishment and maintenance of infection by analyzing expression and regulation of helminth proteins, especially mitochondrial proteins,responding to changing oxygen tension. Achievements:The current research showed: 1)Ascaris suum adult-specific cytochrome b5played the crucial roles in the parasitic adaptation.2)Paragonimus westermani possesses aerobic and anaerobic mitochondria in different tissues, adapting to fluctuating oxygen tension in microaerobic habitats.