Proteomic analyses of Ascaris mitochondrial respiratory chain

目的：本研究旨在通过分析蠕虫蛋白，特别是线粒体蛋白的表达和调节，来阐明感染建立和维持的潜在机制。成就：目前的研究表明：2）卫氏并殖吸虫在不同组织中具有需氧和厌氧线粒体，适应微需氧环境中的氧张力波动。

Objectives:This research project was undertaken to elucidate underlying mechanisms for the establishment and maintenance of infection by analyzing expression and regulation of helminth proteins, especially mitochondrial proteins,responding to changing oxygen tension. Achievements:The current research showed: 1)Ascaris suum adult-specific cytochrome b5played the crucial roles in the parasitic adaptation.2)Paragonimus westermani possesses aerobic and anaerobic mitochondria in different tissues, adapting to fluctuating oxygen tension in microaerobic habitats.