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Functional analysis of motility-related genes of Trypanosoma brucei: relationship with cellular morphology and apoptosis

Functional analysis of motility-related genes of Trypanosoma brucei: relationship with cellular morphology and apoptosis
布氏锥虫运动相关基因的功能分析:与细胞形态和细胞凋亡的关系
批准号:
22590380
负责人:
TAKASHI Suzuki
金额:
$2.33万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
Double knock-down analysis of TbUNC119 and its binding molecule showed cellular apoptosis, morphological change (extended cell shape), and reduced motility in insect-form trypanosome cells. Among those phenotypes, extended cell shape was firstly observed. This was revealed to be at least in part by up-regulated endocytosis. In bloodstream-form trypanosome cells, TbUNC119 was expressed in flagellum and an area around flagella pocket, only in which endocytosis occurred. Functions of TbUNC119 and its binding protein were thus considered to include regulation of cellular endocytosis.
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会议论文
Trypanosome altemative oxidase, a potential therapeutic targct for sleeping sickness, is conserved among Trypanosoma brucei subspecies.
锥虫替代氧化酶是昏睡病的潜在治疗靶标,在布氏锥虫亚种中是保守的。
DOI: --
发表时间: 2010
期刊: Parasitology International
影响因子: 1.9
作者: [Kwansa-Bentum B, Ayi I, Suzuki T,Otchere J, Kumagai T, Anyan WK, Asahi H, Akao N, Wilson MD, Boakye DA, Ohta N, 鈴木高史(中村康介)]
通讯作者: 鈴木高史(中村康介)
Molecular cloning and functional analysis of Trypanosoma brucei motility-related genes.
布氏锥虫运动相关基因的分子克隆及功能分析。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Kwansa-Bentum B, Ayi I, Suzuki T,Otchere J, Kumagai T, Anyan WK, Asahi H, Akao N, Wilson MD, Boakye DA, Ohta N, 鈴木高史(中村康介), 鈴木高史(Kwansa-Bentum Bethel), 大橋光子(鈴木高史)]
通讯作者: 大橋光子(鈴木高史)
Differential KineticActivities of Glycerol Kinase among African Trypanosome Species: Phylogenetc and Therapeutic Implications
非洲锥虫物种中甘油激酶的差异动力学活性:系统发育等和治疗意义
DOI: --
发表时间: 2011
期刊: J Vet Med Sci
影响因子: 1.2
作者: [Ohashi-Suzuki M, Yabu Y, Ohshima S, Nakamura K, Kido Y, Sakamoto K, Kita K, Ohta N, Suzuki T]
通讯作者: Suzuki T
DOI: 10.1111/j.1365-3156.2011.02833.x
发表时间: 2011-10-01
期刊: TROPICAL MEDICINE & INTERNATIONAL HEALTH
影响因子: 3.3
作者: [Kwansa-Bentum, Bethel, Ayi, Irene, Ohta, Nobuo]
通讯作者: Ohta, Nobuo
6
    Electrogenesis Mechanisms of Slow Excitatory and Inhibitory Synaptic Potentials in Hamster Submandibular Ganglion Cells
    • 批准号:
      61570895
    • 项目类别:
      Grant-in-Aid for General Scientific Research (C)
    • 资助金额:
      $1.15万
    • 财政年份:
      1986
    • 负责人:
      TAKASHI Suzuki
    • 依托单位:
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      省市级项目
    • 资助金额:
      --
    • 批准年份:
      2025
    • 负责人:
      吴建平
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    上海市部分规模化养殖场和动物园隐孢子虫和蓝氏贾第鞭毛虫感染现状调查及人兽互传风险探究
    • 批准号:
    • 项目类别:
      省市级项目
    • 资助金额:
      5.0万元
    • 批准年份:
      2024
    • 负责人:
      戴思敏
    • 依托单位:
    桑椹低聚半乳糖调控鼠李糖乳杆菌黏附鞭毛蛋白的作用机制研究