Role of Rab proteins and related host factors in HIV-1 assembly

我们假设某些Rab蛋白在HIV-1的组装和/或释放中发挥作用。在本研究中，我们聚焦于Rab11，它是细胞糖蛋白循环到质膜的重要调节因子之一，并研究了它在HIV-1组装中的潜在作用。用Rab11-Kock down细胞或过表达Rab11突变体的细胞进行的实验结果表明，Rab11通过调节HIV-1包膜糖蛋白的运输参与了感染性病毒粒子的形成。

We hypothesized that some Rab proteins play roles in HIV-1 assembly and/or release. In the present study, we focused on Rab11, one of important regulators of recycling of cellular glycoproteins to the plasma membrane, and examined its potential roles in HIV-1 assembly. The results shown by the experiments using Rab11-kock down cells or cells that over-express Rab11 mutants suggest that Rab11 is involved in the formation of infectious virions by modulating trafficking of the HIV-1 Env glycoproteins.