Role of GANP-mediated hypermutation
Role of GANP-mediated hypermutation
批准号:
22590436
负责人:
MAEDA Kazuhiko
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
Activation-induced cytidine deaminase (AID) is essential to thegeneration for somatic hypermutation at immunoglobulin gene locus. However, it is unclearhow cytoplasmic AID shepherds from cytoplasm to nucleus toward the IgV locus. We studiedthe role of GANP-mediated somatic hypermutation in B cells. We showed that GANP forms acomplex with AID in the cytoplasm and relocated into the nucleus. We found that GANPregulates the recruitment of AID to the immunoglobulin variable regions by modulatingtranscription and nucleosome occupancy.
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GANP controls AID recruitment to immunoglobulin variable region DNA
GANP 控制 AID 募集至免疫球蛋白可变区 DNA
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Maeda K, et al.]
通讯作者:
et al.
高親和性抗体産生のメカニズム
高亲和力抗体产生机制
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[前田和彦, 他]
通讯作者:
他
GANP promotes APOBEC3G encapsidation in virions to reduce viral infectivity
GANP 促进病毒粒子中的 APOBEC3G 衣壳化,以降低病毒感染性
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Maeda K, Singh SK, Ameen AS, Eid MMA, Ikeda T, Koito A, Pham P, Goodman MF, Sakaguchi N.]
通讯作者:
Sakaguchi N.
GANP regulates APOBEC3G targeting for reduction of HIV-1 infectivity
GANP 调节 APOBEC3G 靶向降低 HIV-1 感染性
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Singh SK, Maeda K, Eid MMA, Almofty SA, Shimoda M, Sakaguchi N.]
通讯作者:
Sakaguchi N.
Molecular Mechanism of Immunoglobulin V-Region Diversification Regulated by Transcription and RNA Metabolism in Antigen-Driven B Cells
抗原驱动B细胞转录和RNA代谢调节免疫球蛋白V区多样化的分子机制
DOI:
10.1111/j.1365-3083.2011.02557.x
发表时间:
2011
期刊:
Scandinavian Journal of Immunology
影响因子:
3.7
作者:
[Sakaguchi N, et al]
通讯作者:
et al
共 35 条
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A Porphyromonas gingivalis tyrosine phosphatase is a multifunctional regulator of virulence attributes.
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.75万
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财政年份:2008
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负责人:MAEDA Kazuhiko
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依托单位:
海外基金