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Control of leukocyte migration to inflamed sites and its application to the treatment of refractory inflammatory diseases

Control of leukocyte migration to inflamed sites and its application to the treatment of refractory inflammatory diseases
控制白细胞向炎症部位迁移及其在难治性炎症性疾病治疗中的应用
批准号:
22590433
负责人:
HIRATA Takako
金额:
$3.08万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
Leukocyte migration to inflamed sites is an essential process that occurs during inflammation and immune responses. Control of this process provides a new approach to the treatment of a variety of refractory, inflammatory diseases. In this research project, we identified moesin, an ERM family member, as a molecule that regulates leukocyte migration. We clarified that moesin regulates neutrophil and lymphocytetrafficking in vivo.
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会议论文
Regulation of S1P responsiveness by the ERM protein moesin.
ERM 蛋白 moesin 对 S1P 反应性的调节。
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Nomachi, A]
通讯作者: A
Prostaglandin E2-EP4 signaling mediates UV irradiation-induced systemic immunosuppression by regulating epidermal RANKL expression
前列腺素 E2-EP4 信号通过调节表皮 RANKL 表达介导紫外线照射诱导的全身免疫抑制
DOI: --
发表时间:
期刊: Proceedings of National Academy of Science, U.S.A.
影响因子: --
作者: [前田和彦, 阪口薫雄, Kitipong Soontrapa]
通讯作者: Kitipong Soontrapa
プロスタノイドによる免疫系・神経系調節.
前列腺素类药物调节免疫和神经系统。
DOI: --
发表时间: 2010
期刊: 実験医学
影响因子: --
作者: [平田 多佳子, 古屋敷 智之]
通讯作者: 古屋敷 智之
The ERM protein moesin regulates lymphocyte homeostasis by controlling lymphocyte egress from lymphoid organs
ERM 蛋白 moesin 通过控制淋巴细胞从淋巴器官流出来调节淋巴细胞稳态
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Hirata, T.]
通讯作者: T.
8
    Molecular basis of lymphocyte migration to the skin and mechanisms of acquisition of skin-migrating activity
    • 批准号:
      17590433
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.24万
    • 财政年份:
      2005
    • 负责人:
      HIRATA Takako
    • 依托单位:
    Mechanisms regulating leukocyte rolling mediated by selectin ligand PSGL-1
    • 批准号:
      15590438
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.3万
    • 财政年份:
      2003
    • 负责人:
      HIRATA Takako
    • 依托单位:
    海外基金