Visualization of Biological Changes Induced by the Changes of Japanese Life-style by Analyzing a Clinical Data Accumulated in the IMIS for 30 Years

在高知大学高知医学院医院的医院信息系统IMIS的临床数据库中，选择了准健康的受试者，并进行了重要的临床测试，其值应在一定范围内。将可能受日本人生活方式变化影响的临床试验数据按年龄和出生年限分开进行分析。我们期望通过这种方法可以直观地看到生活方式的改变所引起的生化变化。结果，我们发现血清总胆固醇密度在每个出生年份(1920年代、1930年代、1940年代、1950年代、1960年代)的变化是不同的。然而，在其他临床测试中，我们找不到明显的变化。在这30年里，几项测试的基准都略有变化，这是我们找不到明显变化的原因之一。我们认识到，临床试验的高质量控制对于临床试验的纵向分析至关重要。

The quasi-healthy subjects were selected with their vital clinical tests of which values should be within certain ranges, in a clinical database of the hospital information system IMIS at Kochi Medical School Hospital of Kochi University. Their clinical test data probably affected by the changes of Japanese life-style were analyzed by separating with ages and birth-years. We expected that the bio-chemical changes induced by the changes of life-style could be visualized by this approach. As a result, we found that the total serum cholesterol density were differently changed at each birth-years bin (1920s, 1930s, 1940s, 1950s, 1960s). However, we couldn't find the clear changes on other clinical tests. The baselines of several tests were slightly changed for these 30 years and this is one of reasons why we couldn't find clear changes. We recognized that the high quality control of clinical tests was essential for longitudinal analysis of clinical tests.