Potent in vitro and in vivo antitumor effects of MDM2 inhibitor nutlin-3 in gastric cancer cells

小鼠双分钟2 （MDM2）是p53的负调节因子。一种MDM2抑制剂nutlin-3在野生型p53的胃细胞系中稳定p53并诱导凋亡。在MKN-45异种移植瘤模型中证实了单独使用坚果素-3及5-氟尿嘧啶加用坚果素-3的体内抗肿瘤作用。Nutlin-3对携带野生型p53的人胃癌细胞具有较强的抗肿瘤活性，在单用和与常规抗癌药物联用方面具有较好的应用前景。

Murine double minute 2 (MDM2) is a negative regulator of p53. An MDM2 inhibitor, nutlin-3, stabilized p53 and induced apoptosis in the gastric cell lines with wild-type p53. An in vivo antitumor effect of nutlin-3 alone and its additiveaugmentation by 5-fluorouracil were confirmed in MKN-45 xenograft tumor model. Nutlin-3 showed potent antitumor activity against human gastric cancer cells with wild-type p53 and shows promise as a single agent and in combination with conventional anticancer drugs.