Hyperdry human amniotic membrane is useful material for tissue engineering.: Physical, morphological properties, and safety as the new biological material.
Hyperdry human amniotic membrane is useful material for tissue engineering.: Physical, morphological properties, and safety as the new biological material.
批准号:
22590498
负责人:
OKABE Motonori
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
Human amniotic membrane (AM) has been used widely as graft biomaterial for a variety of clinical applications. But, there are some persistent problems related to the preparation, storage, and sterilization. To resolve these problems, we developed hyperdry AM (HD-AM) using far-infrared rays, depression of air, and microwaves and then sterilized by g-ray irradiation. To elucidate the benefit of HD-AM as biological materials, compare with the histological and physical properties of HD-AM with a freeze-dried AM (FD-AM) as typical freeze-dry methods, evaluate the safety of HD-AM in vivo experiment used nude mice, and demonstrate the feasibility of HD-AM transplant in pterygium. HD-AM has kept the morphological structure of epithelium and connective tissues. The water permeability and the sieving coefficient of HD-AM were significantly lower than that of FD-AM. At 18 months after transplanted, single and multilayers of HD-AM in the intraperitoneal cavity was degraded without any infiltrated cells. For clinical treatment, recurrence of pterygium and regrowth of the subconjunctival fibrosis were not observed during the 6-month follow-up periods after the surgery. It was proposed that HD-AM was a safe and effective new biological material for clinical use including treatment for recurrent pterygium.
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Identification of cancer stem cells to develop new clinical treatment system that I stargeting the cancer stem cells in the field of Obstetrics and Gynecology
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批准号:18591826
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.62万
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财政年份:2006
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负责人:OKABE Motonori
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依托单位: