A new biomarker for atherosclerosis

本研究的目的是从DNA损伤/修复的角度寻找动脉粥样硬化或其综合危险因素的生物标志物。用缺乏DNA损伤反应的动脉粥样硬化小鼠进行的实验表明，DNA损伤修复的异常积累了DNA损伤并加速了动脉粥样硬化。根据实验结果，我们建立了定量检测人单核细胞DNA损伤，尤其是双链断裂的方法。我们证明，这种方法可以准确地检测到动脉粥样硬化的危险因素之一--吸烟。对于预防医学来说，进一步验证该方法是否能综合估计其他危险因素具有重要意义。

The aim of this study is to find a biomarker for atherosclerosis or its comprehensive risk factors from the point of view of DNA damage/repair. The experiments using atherosclerotic mice lacking DNA damage response revealed that abnormality in DNA damage-repair accumulates DNA damage and accelerates atherosclerosis. According to the results, we established the method to quantify DNA damage, especially double strand breaks in human mononuclear cells. We showed that this method precisely detect one of the atherosclerotic risk factors, smoking. It isimportant for preventive medicine to further verify whether this method can estimateother risk factors comprehensively.