Analysis of prognostic predictor for papillary thyroid carcinoma

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Analysis of BRAF mutation in papillary thyroid carcinoma using Fine-needle aspiration (FNA) sample is established in recent 3 years. We showed the relationship between BRAF mutation (T1796A) and clinical malignancy of Japanese PTC using FNA sample. In surgical PTC tissue,BRAF mutation (T1796A) is positive or negative, the direct sequence method revealed PTC with positive BRAF mutation had heterogeneous alleles. We are going to exclude wild type allele such as blood cells, mesenchymal cells and endothelial cells, further investigate the genetic heterogeneity .