Relationship between age-dependent decline in cognitive function and lifestyle-related disease risks in a healthy adult population

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We performed an epidemiological study to explore the relationship between such cognitive functions as memory or attention and various biomarkers. Our subjects were 505 (210 males and 295 females) annual health checkup participants aged 40 or more. Particularly focused in this study was the relationship of serum fatty acid composition (%) and cognitive function. Results indicated that clupanodonic acid and DHA has a statistically significant and borderline significant association, respectively, with low attention only in females, but EPA showed no such associations. Males failed to show any relationships between fatty acid composition and cognitive function.