Elucidation of bone formation signal aimed at the development of medical treatment of osteoporosis induced by deterioration of bone formation
Elucidation of bone formation signal aimed at the development of medical treatment of osteoporosis induced by deterioration of bone formation
阐明骨形成信号，旨在开发骨形成恶化引起的骨质疏松症的药物治疗
批准号：
22590656
负责人：
SUGIMOTO Toshitsugu
金额：
$2.83万
依托单位：
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2010
资助国家：
日本
项目状态：
已结题
起止时间：
2010 至 2012
中文摘要
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英文摘要
We demonstrated that strontium exhibited anabolic action on bone partly through activating calcium-sensing receptor. We identified a smad3-related factor, Tmem119, which is induced by parathyroid hormone(PTH) and promotes osteoblast differentiation partly via Wnt signal and cross-talk with bone morphogenetic protein-Runx2 pathway. Endoplasmic reticulum stress pathway is involved in the differentiation of myoblasts into osteoblasts enhanced by Tmem119. Advanced glycation end-products inhibits osteoblast differentiation via the suppression of this pathway.
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Effects of a single injection of teriparatide on bone turnover barkers in postmenopausal women
单次注射特立帕肽对绝经后妇女骨转换指标的影响
单次注射特立帕肽对绝经后妇女骨转换指标的影响
DOI：
--
发表时间：
2012
期刊：
Osteoporos Int
影响因子：
--
作者：
[Shiraki M, Sugimoto T, Nakamura T]
通讯作者：
Nakamura T
DOI：
10.1055/s-0030-1255091
发表时间：
2010-06
期刊：
Hormone and Metabolic Research
影响因子：
2.2
作者：
[Shin Takaoka;Toru Yamaguchi;S. Yano;M. Yamauchi;T. Sugimoto]
通讯作者：
Shin Takaoka;Toru Yamaguchi;S. Yano;M. Yamauchi;T. Sugimoto
Comparison of serum sclerostin levels among patients with postmenopausal osteoporosis, prmnary hyperparathyroidism and osteomalacia
绝经后骨质疏松症、原发性甲状旁腺功能亢进症及骨软化症患者血清硬化素水平比较
绝经后骨质疏松症、原发性甲状旁腺功能亢进症及骨软化症患者血清硬化素水平比较
DOI：
--
发表时间：
2011
期刊：
Exp Clin Endocrinol Diabetes
影响因子：
--
作者：
[Kaji H, et al]
通讯作者：
et al
Effect of teriparatide on BMD and bone turnover markers in Japanese subjects with osteoporosis at high risk of fracture
特立帕肽对日本骨质疏松症骨折高危受试者 BMD 和骨转换标志物的影响
特立帕肽对日本骨质疏松症骨折高危受试者 BMD 和骨转换标志物的影响
DOI：
--
发表时间：
2010
期刊：
Bone
影响因子：
4.1
作者：
[Miyauchi A, et al]
通讯作者：
et al
DOI：
10.1016/j.bbrc.2011.12.147
发表时间：
2012-02-03
期刊：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
影响因子：
3.1
作者：
[Tanaka, Ken-ichiro, Matsumoto, Erika, Kaji, Hiroshi]
通讯作者：
Kaji, Hiroshi
共 25 条
Research for the elucidation of bone formation signals applied to the development of bone-forming agents
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批准号：18591025
-
项目类别：Grant-in-Aid for Scientific Research (C)
-
资助金额：$2.39万
-
财政年份：2006
-
负责人：SUGIMOTO Toshitsugu
-
依托单位：
Research for the mechanisms of anabolic action of parathyroid hormone(PTH) on bone and interaction between PTH and estrogen in osteoblasts
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批准号：14571064
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项目类别：Grant-in-Aid for Scientific Research (C)
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资助金额：$2.24万
-
财政年份：2002
-
负责人：SUGIMOTO Toshitsugu
-
依托单位：
Research for the role of calcium-sensing receptor in parathyroid gland and bone
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批准号：12671087
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项目类别：Grant-in-Aid for Scientific Research (C)
-
资助金额：$2.18万
-
财政年份：2000
-
负责人：SUGIMOTO Toshitsugu
-
依托单位：
Research for the mechanisms of anabolic action of parathyroid hormone (PTH) and interaction between PTH and estrogen
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批准号：09671060
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项目类别：Grant-in-Aid for Scientific Research (C)
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资助金额：$1.79万
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财政年份：1997
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负责人：SUGIMOTO Toshitsugu
-
依托单位：
Research for role of bone morphogenetic protein in the differentiation and activation of osteoclast and osteoblast
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批准号：07671136
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项目类别：Grant-in-Aid for Scientific Research (C)
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资助金额：$1.47万
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财政年份：1995
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负责人：SUGIMOTO Toshitsugu
-
依托单位：
Reseach for cell-cell communication in bone remodeling and differentiation of osteoblast and osteoclast
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批准号：04671479
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项目类别：Grant-in-Aid for General Scientific Research (C)
-
资助金额：$1.34万
-
财政年份：1992
-
负责人：SUGIMOTO Toshitsugu
-
依托单位：
海外基金