Elucidation of bone formation signal aimed at the development of medical treatment of osteoporosis induced by deterioration of bone formation

我们证明锶对骨的合成代谢作用部分是通过激活钙敏感受体而实现的。我们鉴定了一个smad 3相关因子Tmem 119，它由甲状旁腺激素（PTH）诱导，部分通过Wnt信号和与骨形态发生蛋白-Runx 2通路的交叉作用促进成骨细胞分化。内质网应激途径参与Tmem 119促进成肌细胞向成骨细胞分化。晚期糖基化终产物通过抑制该途径抑制成骨细胞分化。

We demonstrated that strontium exhibited anabolic action on bone partly through activating calcium-sensing receptor. We identified a smad3-related factor, Tmem119, which is induced by parathyroid hormone(PTH) and promotes osteoblast differentiation partly via Wnt signal and cross-talk with bone morphogenetic protein-Runx2 pathway. Endoplasmic reticulum stress pathway is involved in the differentiation of myoblasts into osteoblasts enhanced by Tmem119. Advanced glycation end-products inhibits osteoblast differentiation via the suppression of this pathway.