Analysis of the mechanism of gastric tumorigenesis using mice with stomach-specific gene recombination

本研究的目的是建立胃特异性基因重组小鼠，为研究胃肿瘤的发生发展奠定基础。利用该模型建立了高重复性的胃肿瘤模型，并对其致癌机制进行了分析。我们发现多种细胞因子和细胞内激酶参与了胃癌的发生。在基因敲除小鼠和用siRNA和抑制剂处理的胃癌细胞系中，阐明了每个分子的作用。

The aim of this study was to establish stomach-specific gene recombination mice for the research of gastric tumorigenesis. Using this model, we established highly reproducible gastric tumor model and analyzed the mechanism of carcinogenesis. We found several cytokines and intracellular kinases were involved in the gastric carcinogenesis. Role of each molecule was clarified using knockout mice and gastric cancer cell lines treated with siRNA and inhibitors.