Effects on esophageal motor disorder by capsaicin-sensitive nerves in patients with diabetes

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The mRNA expression levels of TRPV1, TRPV2, and TRPA1 in the upper and lower esophagus, and dorsal root ganglion of normal rats were examined using immunohistological and molecular biological techniques. mRNA expression levels were highest in the dorsal root ganglion, while no differences were observed between the upper and lower esophagus. In contrast, in a rat model of reflux esophagitis, the mRNA expression levels of TRPV1, TRPV2, and TRPA1 tended to be higher in the upper as compared to the lower esophagus. In our previous studies of normal subjects and patients with reflux esophagitis, no site-specific differences in regard to the levels of mRNA expression in the esophagus have been observed.