Functional analysis of tight junction protein: claudins on the development and progression of gastric cancer

紧密连接蛋白的功能分析：claudins与胃癌发生发展的关系

• 批准号: 22590691
• 负责人: OSHIMA Tadayuki
• 金额: $ 2.75万
• 依托单位: Hyogo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590691/
• 关键词: 上部消化管学(食道,胃,十二指腸); 胃癌; 細胞間接着装置; タイト結合; クローディン

The morbidity of gastric cancer is still high in Japan, and it is know that Helicobacter pylori infection is involved in the development of gastric cancer. However, the incidence of gastric cancer in Helicobacter pylori infected people is a couple of %. We focused on tight junction proteins as the factor related to the development of gastric cancer and the malignancy. Down-regulation of claudin-3 was associated with proliferative potential of gastric cancer cells. Furthermore, down-regulation of claudin-18 at the invasive front of gastric cancer was associated with the proliferative and invasivepotential, suggesting that they have pivotal roles in gastric cancer progression.

胃癌在日本的发病率仍然很高，并且已知幽门螺杆菌感染与胃癌的发展有关。然而，幽门螺杆菌感染者胃癌的发病率为百分之几。我们关注紧密连接蛋白作为胃癌和恶性肿瘤发生发展的相关因素。claudin-3的下调与胃癌细胞的增殖潜能有关。此外，claudin-18在胃癌侵袭前的下调与增殖和侵袭潜能有关，表明它们在胃癌进展中起关键作用。

项目成果

Down-regulation of claudin-4 and up-regulation of claudin-18 are associated with proliferative potential of intramucosal gastric cancer.

Claudin-4 的下调和 Claudin-18 的上调与粘膜内胃癌的增殖潜力相关。

• 发表时间: 2010
• 作者: Chen X;Oshima T;Sakurai J;Tanaka J;Morita T;Tomita T;Kim Y;Hori K;Watari J;Matsumoto T;Miwa H.
• 通讯作者: Miwa H.

Watari J, Fujimori T, Miwa H. Groαpromotes invasion of gastric cancer cells.

Watari J，Fujimori T，Miwa H.Groα促进胃癌细胞的侵袭。

• 发表时间: 2013
• 作者: Fukui H;Zhang X;Sun C;Yamasaki T;Kondo T;Ikehara H;Tomita T;Oshima T
• 通讯作者: Oshima T

Multiple gastric polypoid lesions with protein-losing enteropathy.

多发性胃息肉样病变伴蛋白质丢失性肠病。

• 发表时间: 2011
• 期刊: Intern Med. 査読有
• 作者: Sakurai J;Watari J;Oshima T;Miwa H.
• 通讯作者: Miwa H.

胃粘膜内癌におけるクローディンの発現と増殖能は相関する.奥川卓也,大島忠之

胃粘膜内癌中 Claudin 的表达与增殖能力存在相关性。

• 发表时间: 2010
• 作者: Chen Xin,神谷紀子,豊島史彦,櫻井淳;田中淳二,森田毅,富田寿彦,堀和敏,渡 二郎,松本譽之,三輪洋人.
• 通讯作者: 田中淳二,森田毅,富田寿彦,堀和敏,渡 二郎,松本譽之,三輪洋人.

胃粘膜内癌におけるクローディンの発現と増殖能は相関する

胃粘膜癌中Claudin表达与增殖能力相关

• 发表时间: 2010
• 作者: 奥川卓也;大島忠之;ら
• 通讯作者: ら