The functional analysis of IL-7 receptor in colitogenic memory Tcell.

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As the final goal for the development of epoch-making radical treatment to inflammatory bowel disease (IBD), we have focused "colitogenic memory T cell" that continues being underlying in the body throughout the life. We have then proved the importance of the IL-7/IL-7 receptor (IL-7R) signal in the mechanism for the maintenance of colitogenic memory T cell and the importance of IL-7R signaling in colitis model. IL-7Rα was expressed in CD4+T cell in both normal mouse and colitis mouse. And the expression of IL-7Rα was up-regulated in the CD4+T cell with the onset of the colitis. These results suggested that IL-7/IL-7R signal in the CD4+T cell might be novel target for the therapy of the inflammatory bowel diseases.