The effect of inhibition of pancreatic fibrosis by IL-10.

几种炎性细胞因子诱导胰腺血管内皮细胞表达MAdCAM-1，增加内皮通透性。提示IL-10抑制了MAdCAM-1的表达，从而抑制了淋巴细胞的浸润。在天蓝色诱导的小鼠胰腺炎模型中，IL-10诱导药物被认为对胰腺炎有效，因为小鼠体重和血清淀粉酶水平的增加被醋酸格拉替雷默诱导IL-10表达的抑制。因此，il -10诱导药物的进展有助于胰腺炎的治疗。

Several inflammatory cytokines induced expression of MAdCAM-1 on the vascular endothelial cells of pancreas and increased permeability of endothelium. It was suggested that infiltration of lymphocytes were inhibited by IL-10 because IL-10 inhibited expression of MAdCAM-1. In cerulean-induced pancreatitis model of mice, IL-10-inducing drugs were considered effective against pancreatitis because the increasing of body weight and serum amylase levels of mice ware inhibited by glatiramer acetate which induced expression of IL-10. Consequently, progression of IL-10-inducing drugs are contributable for the therapy of pancreatitis.