The effect of class III antiarrhythmic drugs for transmural dispersion of repolarizationin canine heart with myocardial infarction

Ⅲ类抗心律失常药物对心肌梗死犬心脏跨壁复极离散度的影响

• 批准号: 22590795
• 负责人: YOSHIOKA Koichiro
• 金额: $ 2.83万
• 依托单位: Tokai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590795/
• 关键词: イヌ心筋梗塞モデル; Kチャネル遮断薬; 不整脈基質; 致死性不整脈; 心肺停止モデル; 動物モデル; III群抗不整脈薬; 貫壁性再分極時間; プランジ実験; 再分極; マッピング実験

Background: Nifekalant (NIF) and Amiodarone (AMD) are both class III antiarrhythmic drugs, however displayed a different pharmacological effect. The aim of this study is investigate the electrical-characteristics of these 2 agents for ventricular tachycardia/fibrillation (VT/VF) in cardiopulmonary resuscitation (CPR) using canine ischemic model. Methods and Results: Beagle dogs (n=16) under anesthesia were created with a myocardial infarction, and then VT/VF induction by continuous stimulation and CPR were repeated. NIF (0.15-0.3mg/kg) or AMD (5mg/kg) was administered under acidosis conditions. The QTc interval measured by Y-lead ECG showed no significant prolongationbefore and after agents. The activation time (AT) and dispersion of activation recovery interval (ARID) measured by 64-lead left ventricular surface mapping showed little change of AT and decreasing of ARID by NIF, while increasing of AT and decreasing of ARID by AMD (p

背景：尼非卡兰（NIF）和胺碘酮（AMD）均为III类抗肿瘤药物，但药理作用不同。本研究的目的是利用犬缺血模型研究这两种药物在心肺复苏（CPR）中对室性心动过速/室颤（VT/VF）的电特性。方法与结果：麻醉下的比格犬（n=16）造成心肌梗死，然后重复连续刺激诱发VT/VF和CPR。在酸中毒状态下给予NIF（0.15-0.3mg/kg）或AMD（5 mg/kg）。用药前后心电图Y导联QTc间期无明显延长。64导联左室表面标测的激动时间（AT）和激动恢复间期离散度（ARID）显示，NIF对AT无明显影响，而AMD则使AT增加，ARID缩短（P