The effect of class III antiarrhythmic drugs for transmural dispersion of repolarizationin canine heart with myocardial infarction

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Background: Nifekalant (NIF) and Amiodarone (AMD) are both class III antiarrhythmic drugs, however displayed a different pharmacological effect. The aim of this study is investigate the electrical-characteristics of these 2 agents for ventricular tachycardia/fibrillation (VT/VF) in cardiopulmonary resuscitation (CPR) using canine ischemic model. Methods and Results: Beagle dogs (n=16) under anesthesia were created with a myocardial infarction, and then VT/VF induction by continuous stimulation and CPR were repeated. NIF (0.15-0.3mg/kg) or AMD (5mg/kg) was administered under acidosis conditions. The QTc interval measured by Y-lead ECG showed no significant prolongationbefore and after agents. The activation time (AT) and dispersion of activation recovery interval (ARID) measured by 64-lead left ventricular surface mapping showed little change of AT and decreasing of ARID by NIF, while increasing of AT and decreasing of ARID by AMD (p