The regulation of endothelial migration and angiogenesis by transcriptiona l coact I vator PGC-1aIpha

严重肢体缺血是导致截肢的主要原因，影响10- 15%的糖尿病人群，因此迫切需要开发有效的治疗手段。糖尿病患者肢体缺血的高发病率在很大程度上是由于糖尿病患者无法制造新的血管（称为血管生成的过程）来恢复缺血组织的血液供应。然而，这种情况的基本机制在很大程度上还没有确定。在本研究中，我们证明糖尿病增加了内皮细胞中转录辅激活因子PGC-1α的丰度，从而使内皮细胞对血管生成因子无反应，并导致糖尿病血管生成能力降低。

Critical limb ischemia, the leading cause oflimb amputation, affects 10-15%ofdiabetic population, thus calling for critical needs to develop effective therapeutic means. The high prevalence oflimb ischemia in diabetes is in significant part caused by the inability of diabetics to elaborate new blood vessels (the process called angiogenesis) to resume blood supply in ischemic tissues. However, the underlying mechanism fbr this has been largely undefined. In the present study, we demonstrated that diabetes increases the abundance oftranscriptional co-activator PGC-1αin endothelial cells, which then renders endothelial cells unresponsive to angiogenic factors, and causes diminished angiogenic capacity in diabetes.