Prediction of progression and efficacy of early treatment for asymptomatic pulmonary arterial hypertension

无症状肺动脉高压的进展和早期治疗疗效的预测

• 批准号: 22590781
• 负责人: YAMADA Norikazu
• 金额: $ 2.83万
• 依托单位: Mie University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590781/
• 关键词: 臨床心血管病態学; 肺高血圧症; 運動負荷; 薬物治療; 早期介入; 循環器内科; 運動負荷試験; 循環器

In the patients who have the risks of pulmonary arterial hypertension and positive response in right heart catheterization under exercise, mean pulmonary arterial pressure had not increased to the level of pulmonary hypertension during observational period. But the abnormal responses during exercise had improved in the pharmacological intervention group compared with no intervention group. Early pharmacological intervention might be effective for patients with borderline pulmonary arterial hypertension to prevent pulmonary vascular remodeling.

在有肺动脉高压风险且右心导管运动阳性的患者中，观察期间平均肺动脉压未升高至肺动脉高压水平。但药物干预组运动时的异常反应较未干预组有所改善。早期药物干预对临界性肺动脉高压患者肺血管重构的预防可能是有效的。

项目成果

肺動脈性肺高血圧症の早期診断における運動負荷下右心カテーテル検査の有用性と課題.

运动下右心导管插入术在肺动脉高压早期诊断中的效用和挑战。

• 发表时间: 2012
• 作者: 伊藤理;長谷川好規.;山田典一
• 通讯作者: 山田典一

Abnormal response of total pulmonary resistance during exercise in patients with borderline pulmonary arterial hypertension associated with connective tissue diseases

结缔组织病相关边缘性肺动脉高压患者运动时总肺阻力异常反应

• 发表时间: 2012
• 作者: Akimasa Matsuda;Norikazu Yamada
• 通讯作者: Norikazu Yamada

Abnormal response of total pulmonary resistance during exercise in patients with borderline pulmonary arterial

交界性肺动脉患者运动时总肺阻力的异常反应

• 发表时间: 2012
• 作者: Akimasa Matsuda;Norikazu Yamada
• 通讯作者: Norikazu Yamada

肺動脈性肺高血圧症の早期診断における運動負荷下右心カテーテル検査の有用性と課題

运动状态下右心导管检查在肺动脉高压早期诊断中的效用和挑战

• 作者: Ito S;Hasegawa Y;大河原雄一;山田典一
• 通讯作者: 山田典一

Abnormal response of total pulmonary resistance during exercise in

运动时总肺阻力的异常反应

• 发表时间: 2012
• 作者: Akimasa Matsuda;Norikazu Yamada
• 通讯作者: Norikazu Yamada