Establishment of immune complex-mediated disease models by human patient sera

利用人类患者血清建立免疫复合物介导的疾病模型

• 批准号: 22590885
• 负责人: TSUBOI Naotake
• 金额: $ 2.75万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590885/
• 关键词: 好中球; 全身性ループスエリテマトーデス; インテグリン; Fc 受容体; Fc受容体; 自己免疫疾患; 免疫複合体; Fcγ受容体

In newly established animal model of lupus nephritis induced by passive transfer of human systemic lupus erhythematosus (SLE) sera, essential role of human FcγRIIA and protective role of Mac-1 for disease induction were elucidated. The Pristine-induced SLE model demonstrated dual roles of Mac-1 as promoting pulmonary hemorrhage and as protective against lupus nephritis.

在新近建立的人系统性狼疮（SLE）血清被动转移诱导的狼疮性肾炎动物模型中，阐明了FcγRIIA在疾病诱导中的重要作用和Mac-1的保护作用。Pristine诱导的SLE模型显示Mac-1的双重作用，即促进肺出血和保护免受狼疮性肾炎。

项目成果

Asymptomatic diverticulosis identified by computed tomography is not a risk factor for enteric peritonitis

• DOI: 10.1093/ndt/gfr685
• 发表时间: 2012-06-01
• 期刊: NEPHROLOGY DIALYSIS TRANSPLANTATION
• 影响因子: 6.1
• 作者: Toda, Susumu;Ito, Yasuhiko;Matsuo, Seiichi
• 通讯作者: Matsuo, Seiichi

Endothelial CD47 promotes vascular endothelial-cadherin tyrosine phosphorylation and participates in T cell recruitment at sites of inflammation in vivo.

• DOI: 10.4049/jimmunol.1103606
• 发表时间: 2012-09-01
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: Azcutia V;Stefanidakis M;Tsuboi N;Mayadas T;Croce KJ;Fukuda D;Aikawa M;Newton G;Luscinskas FW
• 通讯作者: Luscinskas FW

リツキシマブが有効であったクリオグロブリン血症の一例

利妥昔单抗有效的冷球蛋白血症一例

• 发表时间: 2010
• 作者: Ohya Y;Okamoto S;Tasaki M;Ueda M;Jono H;Obayashi K;Takeda K;Okajima H;Asonuma K;Hara R;Tanihara H;Ando Y;Inomatal Y;早崎貴洋
• 通讯作者: 早崎貴洋

疣贅PCRによりStaphylococcus warneriを起因菌と同定できた感染性心内膜炎の1例

感染性心内膜炎一例，通过疣 PCR 鉴定为华氏葡萄球菌为致病菌。

• 发表时间: 2011
• 作者: 池田洋一郎;他;Hiroshi Kojima;許波;Hibiki Shinjo;Hiroshi Kinashi;伊藤功
• 通讯作者: 伊藤功

Human lupus serum induces neutrophil-mediated organ damage in mice that is enabled by Mac-1 deficiency.

• DOI: 10.4049/jimmunol.1201594
• 发表时间: 2012-10-01
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: Rosetti F;Tsuboi N;Chen K;Nishi H;Ernandez T;Sethi S;Croce K;Stavrakis G;Alcocer-Varela J;Gómez-Martin D;van Rooijen N;Kyttaris VC;Lichtman AH;Tsokos GC;Mayadas TN
• 通讯作者: Mayadas TN