Roles of Foxc transcription factors in podocyte injury.

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This project is aimed to clarify roles of Foxc1 and Foxc2 in the kidney development and the development of glomerular sclerosis. Mice carrying null mutated Foxc1 gene frequently develop anomalous double collecting system due to ectopic budding. However, ectopic budding per se does not contribute to kidney dysplasia. It is intriguing that Foxc1 expression does not affect the fate of metanephric mesenchyme where it is expressed but controls the site of bud formation by the Wolffian duct. We are analyzing kidney tissues from Foxc2 null mice, podocyte specific Foxc1 knockoutmice. We also generated Foxc2 loxP mice that enable us to generate kidney specific Foxc2 conditional knockout mice.