The Role of Crosstalk between ChREBP and Clock-related genes in the Development of Metabolic syndrome

我们研究了碳水化合物反应元件结合蛋白（ChREBP）和时钟相关基因（Klf-10和Ppara）之间的串扰在代谢综合征发生中的作用。利用ChREBP和生物钟相关基因之间的反馈回路是调节代谢途径和昼夜节律的常用方法。考虑到代谢综合征中代谢和昼夜节律紊乱并存，抑制ChREBP的活性将有利于预防代谢综合征。

We studied the role of crosstalk between carbohydrate-responsive element-binding protein (ChREBP) and clock-related genes (Klf-10 and Ppara) in the development of metabolic syndrome. Use of the feedback loop between ChREBP and clock-related genes is a common method for regulating both metabolic pathways and the circadian rhythm. Considering disorders in both metabolism and circadian rhythm coexist in metabolic syndrome, suppression of ChREBP transactivities will be beneficial in preventing metabolic syndrome.