The elucidation of antihyperglycemic action mechanism in the liver and pancreatic beta cells of bile acid resin

点击翻译按钮获取中文摘要

The objective of this study was to assess the chronic effects of a bile acid sequestrant, colestimide, on glucose metabolism in type 2 diabetes..Colestimide significantly reduced the elevated fasting blood glucose level, and CA even more markedly reduced fasting blood glucose. A hyperinsulinemic-euglycemic clamp study revealed that colestimide alleviated insulin resistance by suppressing hepatic glucose production and increasing peripheral glucose usage. Colestimide suppressed SHP expression, but enhanced SREBP2 expression. On the other hand, CA increased the expression of SHP and lipogenic enzymes such as ACC and SCD-1, but had no effect on SREBP2.