Functional analysis of AIF molecule and developement of therapy of rheumatoid arthritis

同种异体移植炎性因子（Alograftinflammatoryfactor，AIF）-1在大鼠心脏移植慢性排斥反应中被发现，并被认为参与免疫应答，但其分子功能尚不完全清楚。本研究采用高密度寡核苷酸芯片技术比较rhAIF-1刺激后外周血单个核细胞mRNA表达谱的变化。由于AIF-1在单核细胞中的生物学活性，我们表明AIF-1诱导IL-6和许多趋化因子，导致趋化性和组织纤维化。

Functional analysis of AIF molecule and developement of therapy of rheumatoid arthritisAllograft inflammatory factor (AIF)-1 has been identified in chronic rejection of rat cardiac allografts and is thought to be involved in the immune response, however its molecular function is not fully understood. In this study , we compared mRNA expression profile of rhAIF-1 stimulated peripheral blood mononuclear cells by using the high-density oligonucleotide microarray technique. As biological activity in mononuclear cells of AIF-1, we indicated that AIF-1 induced IL-6 and many chemokines leading to chemotaxis and tissue fibrosis.