Identification of novel citrullinated antigen of RA, prospects for the pathogenesis of rheumamtoid arthritis and biomarkers

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Although anti-citrullinated peptide (ACPA) is specific for rheumatoid arthritis (RA), the pathogenic citrullinated autoantigen relevant for RA remains to be elucidated. In the present study, we have demonstrated the specific presence of citrullinated cellular fibronectin in RA synovial fluids, which could be involved in the pathogenesis of RA thorough formation of immune complexes within the affected joints. Additionally, we demonstrated the correlation of anti-MCV (mutated citrullinated vimentin) antibody with the number of tender/swollen joints, suggesting that anti-MCV antibody might be useful for monitoring RA disease activity.