Effect of histamine H4 and H1 receptor on allergic diseases

组胺H4和H1受体对过敏性疾病的影响

• 批准号: 22591099
• 负责人: SEIKE Masahiro
• 金额: $ 2.91万
• 依托单位: Sagami Women's Junior College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591099/
• 关键词: アレルギー皮膚炎; ヒスタミン H1 受容体拮抗剤; ヒスタミン H4 受容体拮抗剤; アレルギー性接触皮膚炎; ヒスタミンH1受容体; ヒスタミンH4受容体; Th1; Th2; 慢性アレルギー性接触皮膚炎; ヒスタミンH1受容体拮抗剤; ヒスタミンH4受容体拮抗剤; アレルギー性皮膚炎; ヒスタミン; Th17

Histamine facilitates development of eczematous lesions in chronic allergic contact dermatitis. In addition to the well-known corticosteroid treatment, histamine H1 receptor (H1R) antagonists also have been used. This study observed effects of histamine H4 receptor (H4R) antagonist usage with H1R antagonist in a murine chronic allergic contact dermatitis model, developed by repeated percutaneous challenge to the dorsal skin with 2,4,6-trinitro-1-chlorobenzene (TNCB). The H1R antagonist olopatadine hydrochloride and/or the H4R antagonist JNJ7777120 were then administered. Combination therapy was more effective than H1R antagonist monotherapy. Serum IgE and levels of interleukin (IL)-4, IL-5 and IL-6 (Th2 cytokines) in eczematous lesions decreased with combined therapy. Combined therapy with H1R and H4R antagonists counteracts the disadvantages of each as monotherapeutic agents and potentially represents a new strategy for the treatment of chronic allergic contact dermatitis.

组胺促进慢性变应性接触性皮炎湿疹性病变的发展。除了众所周知的皮质类固醇治疗外，还使用了组胺H1受体（H1 R）拮抗剂。本研究观察了组胺H4受体（H4 R）拮抗剂与H1 R拮抗剂联合使用对小鼠慢性变应性接触性皮炎模型的影响，该模型通过反复经皮激发背部皮肤2，4，6-三硝基-1-氯苯（TNCB）而建立。然后给予H1 R拮抗剂盐酸奥洛他定和/或H4 R拮抗剂JNJ 7777120。联合治疗比H1 R拮抗剂单药治疗更有效。湿疹皮损中IL-4、IL-5和IL-6（Th 2细胞因子）水平和血清IgE水平在联合治疗后均下降。H1 R和H4 R拮抗剂的联合治疗抵消了各自作为单药的缺点，并可能代表治疗慢性变应性接触性皮炎的新策略。

项目成果

皮膚機能に対するマンゴー摂取効果

摄入芒果对皮肤功能的影响

• 发表时间: 2011
• 期刊: 相模女子大学紀要
• 作者: 松下亜由子;濱田久美子;清家正博
• 通讯作者: 清家正博

Advantages of histamine H4 receptor antagonist usage with H1 receptor antagonist for the treatment of murine allergic contact dermatitis

• DOI: 10.1111/j.1600-0625.2012.01559.x
• 发表时间: 2012-09-01
• 期刊: EXPERIMENTAL DERMATOLOGY
• 影响因子: 3.6
• 作者: Matsushita, Ayuko;Seike, Masahiro;Ohtsu, Hiroshi
• 通讯作者: Ohtsu, Hiroshi

アレルギー性接触皮膚炎とIL-17

过敏性接触性皮炎和 IL-17

• 发表时间: 2011
• 作者: 清家正博;松下亜由子
• 通讯作者: 松下亜由子

European Cooeration in Science and Technology

欧洲科技合作

• 作者: W Baumer;T Werfel;R Seifert;M Kietzmann;D Neumann;R Khanferyan;H Ohtsu;M Seike;E Masini;SE Dahlen;A Sydbom;R Gutmer
• 通讯作者: R Gutmer