Analysis of Human Regenerated Bone Marrow and Hematopoietic StemCell/Leukemic Stem Cell Niche

人类再生骨髓和造血干细胞/白血病干细胞生态位分析

• 批准号: 22591169
• 负责人: UEDA Takahiro
• 金额: $ 2.83万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591169/
• 关键词: 小児血液学; 造血幹細胞; 白血球幹細胞; 脂肪幹細胞; 人工骨髄; ニッチ; 白血病幹細胞; NOGマウス

Regenerated bone marrow prepared using human mesenchymal cells have the ability to provide a bone marrow niche because long-term maintenance of human hematopoietic cells under the skin of the NOD mouse, an immune-deficient mouse, is possible. On the other hand, a function analysis of regenerated bone marrow prepared from adipose-derived stromal cells of mice revealed that this regenerated bone marrow can provide an environment (bone marrow niche) that is capable of maintaining the ability to self-renew as well as the multilineage potential of hematopoietic cells.

使用人间充质细胞制备的再生骨髓具有提供骨髓生态位的能力，因为人造血细胞在NOD小鼠（免疫缺陷小鼠）的皮肤下的长期维持是可能的。另一方面，从小鼠脂肪来源的基质细胞制备的再生骨髓的功能分析显示，该再生骨髓可以提供能够维持造血细胞的自我更新能力以及多谱系潜能的环境（骨髓生态位）。

项目成果

Hematopoiesis in regenerated bone marrow from adipose-derived stromal cells on the hydroxyapatite scaffold

羟基磷灰石支架上脂肪源性基质细胞再生骨髓中的造血作用

• 发表时间: 2010
• 作者: T. Ueda;A. Fujita;M. Migita;et al.
• 通讯作者: et al.