Analysis of Human Regenerated Bone Marrow and Hematopoietic StemCell/Leukemic Stem Cell Niche

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Regenerated bone marrow prepared using human mesenchymal cells have the ability to provide a bone marrow niche because long-term maintenance of human hematopoietic cells under the skin of the NOD mouse, an immune-deficient mouse, is possible. On the other hand, a function analysis of regenerated bone marrow prepared from adipose-derived stromal cells of mice revealed that this regenerated bone marrow can provide an environment (bone marrow niche) that is capable of maintaining the ability to self-renew as well as the multilineage potential of hematopoietic cells.