Impact of Congenital Cytomegalovirus and Human Herpersvirus-6Infections: A Cohort Study in Nagasaki Prefecture

我们对出生或居住在长崎县的患有以下疾病的婴幼儿进行登记：双侧深度感音神经性耳聋、先天性脑积水、难治性癫痫（主要为West综合征）和广泛性发育障碍（PDD），并采集其干脐带或干血斑标本进行巨细胞病毒（CMV）和人类疱疹病毒6型（HHV-6）DNA检测。我们可以证明先天性巨细胞病毒感染的一些婴儿，包括两名儿童与PDD，然而，HHV-6 DNA没有检测到任何这些标本。

We have registered infants and toddlers who were born or lived in Nagasaki Prefecture with any of the following medical problems: bilateral profound sensorineural hearing loss, congenital hydrocephalus, refractory epilepsy (mostly, West syndrome) and pervasive developmental disorder (PDD).We collected their dried umbilical cord or dried blood spot specimens for detection of cytomegalovirus (CMV) and human herpesvirus-6 (HHV-6) DNA. We could demonstrate congenital CMV infection in some of those infants including two children with PDD; however, HHV-6 DNA was not detected from any of those specimens.