The pathophysiology of NLR ligand-induced coronary arteritis like Kawasaki disease

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In NLR ligand-induced coronary arteritis model like Kawasaki disease, the lesion of coronary artery showed higher expression of various cytokine’s and chemokine’s genesthan those of other blood vessels, suggesting that intrinsic factors of each vascular tissue were important on this site-specific vascular inflammation. Furthermore, the frequency and severity of this coronary arteritis were enhanced by priming of various bacterial component. This model could explain the site-specific vascular inflammation and diversity of etiology in Kawasaki disease.