Role of Ubiquitin specific protease 40 in Glomerulus

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Unbiased transcriptome profiling and functional genomics approaches identified USP40, a family of deubiquitinating enzyme, as being a transcript highly specific for the glomerulus. But its protein characterization and biologic function is not known at all. USP40 may stabilize HINT1 which is known to up-regurate cellular level of cycln-dependent kinase inhibitor p27kip1, by its ubiquitinating activity, thereby influencing the glomerular deveropmental process via modulating cell cycle system of glomerular endotherial cells and podocytes.