Effect of prenatal environment on stress response in offspring

产前营养不良与成人疾病风险增加有关。我们对怀孕小鼠进行了50%的食物限制，并对胎儿肝脏进行了整体基因表达和启动子DNA甲基化分析。我们成功地发现了与心脏病相关的基因，如trib1，以及许多与免疫系统和糖皮质激素信号传导相关的基因。这些搜索到的基因可能有助于预测胎儿期的营养环境，以及胎儿环境引起的成人疾病的风险。

Prenatal undernutrition has been associated with increased risks of adult diseases. We treated pregnant mice with 50% food restriction, and performed global gene expression and promoter DNA methylation profiling on the fetal livers. We successfully found genes such as trib1 which has been associated with heart diseases, and many genes related to the immune system, and glucocorticoid signaling. These searched genes may be useful to predict nutritional environment during fetal period, and risks of adult diseases due to fetal environments.