Regulation of the IL-31 function by the blocking antibody to IL-31 receptor
Regulation of the IL-31 function by the blocking antibody to IL-31 receptor
批准号:
22591230
负责人:
SAITO Saburo
金额:
$2.91万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
To analyze the pleiotropic functions of IL-31, specific antibodies to IL-31 receptor A (IL-31R) were established. These antibodies will be useful tools for analysis of localization of the IL-31R-expressing cells and IL-31 function by administration into mice. Furthermore, to investigate the function of IL-31 or the IL-31 receptor, 2 strains of IL-31 or IL-31 receptor (IL-31R) knockout/LacZknockin mice were generated. To produce offspring with a genetic identity for the analysis of the pleiotropic functions of IL-31, the heterozygous mouse will be backcrossed 7 or more times into the C57BL/6J genetic background.
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会议论文
IL-31によるIgE産生増強とその機序
IL-31增强IgE产生及其机制
DOI:
--
发表时间:
2010
期刊:
臨床免疫・アレルギー科
影响因子:
--
作者:
[Nakajima H, Nakajima K, Tarutani M, Sano S, 中島英貴,志賀建夫,高田智也,樽谷勝仁,佐野栄紀, Nakamura Y. et al., Nakamura Y. et al., 斎藤三郎,秋山暢丈]
通讯作者:
斎藤三郎,秋山暢丈
インターロイキン31)IL-31.矢田純一・宮坂信之編集.サイトカインのすべて:第57巻特別増刊号
白细胞介素 31) IL-31,矢田淳一 (Junichi Yada) 和宫坂伸之 (Nobuyuki Miyasaka) 编辑:第 57 卷特刊。
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Nakajima H, Nakajima K, Tarutani M, Sano S, 中島英貴,志賀建夫,高田智也,樽谷勝仁,佐野栄紀, Nakamura Y. et al., Nakamura Y. et al., 斎藤三郎,秋山暢丈, 斎藤三郎]
通讯作者:
斎藤三郎
Analysis of the mechanism of alopecia and pruritis induced by IL-31
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批准号:19591329
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
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财政年份:2007
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负责人:SAITO Saburo
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依托单位:
Animal model for severe alcoholic hepatitis by chronic ethanol feeding and immunization with fusions of dendritic cells and acetaldehyde adducts.
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批准号:11670538
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:1999
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负责人:SAITO Saburo
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依托单位: