Generation and analysis of model mouse for psoriatic arthritis

我们将银屑病模型小鼠与自身免疫性关节炎模型小鼠杂交，发现双转基因小鼠在背部、尾部和腿部自发发生银屑病皮损。它们还从2或3周龄开始在后足足趾中以高达75%的高频率出现香肠样肿胀。组织学上，他们表现出弥漫性水肿，在真皮以及附着点炎，类似于人类银屑病关节炎。手指病变表现出Th17和Th1细胞因子的转录水平增加。

We crossed psoriasis model mice with autoimmune arthritis model mice, and found that the double transgenic mice spontaneously developed psoriatic skin lesion on the back, tail and legs. They also developed sausage-like swelling in the digits of hind feet from as early as 2 or 3 weeks of age at a high frequency up to 75%. Histologically, they demonstrated diffuse edema in the dermis as well as enthesitis, resembling human psoriatic arthritis. The digit lesions demonstrated increased transcriptional levels of Th17 and th1 cytokines.