Aberrant epidermal expression of semaphorin 3A in pruritic skin diseases and development of new therapeutic drugs for pruritus

瘙痒性皮肤病中信号蛋白3A表皮异常表达及瘙痒新治疗药物的开发

• 批准号: 22591247
• 负责人: AIHARA Michiko
• 金额: $ 3万
• 依托单位: Yokohama City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591247/
• 关键词: 皮膚免疫; 炎症学; セマフォリン3A; アトピー性皮膚炎; かゆみ; 乾癬; コラーゲントリペプチド; C-ファイバー; 治療; アレルギー性鼻炎; シクロスポリン

Semaphorin-3A (Sema3A) expression was lower in pruritic skin disorders compared with the healthy samples, whereas nerve growth factor (NGF) expression was higher. Intranasal administration of recombinant Sema3A in the allergic rhinitis model mice alleviated symptoms. Oral administration of collagen tripeptide in dry skin model mice suppressed scratching behavior and corrected Sema3A and NGF balance. In conclusion, we propose that administration and induction of Sema3A expression may useful to control the outgrowth of C-fibres, leading to pruritus, as a new therapeutic strategy for pruritic disorders.

与健康样本相比，鲁ritic型皮肤疾病的Semaphorin-3a（SEMA3A）表达较低，而神经生长因子（NGF）表达更高。过敏性鼻炎模型小鼠中重组SEMA3A的鼻内给药可缓解症状。在干燥皮肤模型小鼠中口服胶原蛋白肽的口服抑制了刮擦行为，并校正了SEMA3A和NGF平衡。总之，我们建议，SEMA3A表达的给药和诱导可能有助于控制C纤维的生长，导致瘙痒，这是一种新的核疾病治疗策略。

项目成果

Decreased Semaphorin-3A Expression in the Lesional Skin of Patients with Psoriasis Vulgaris

寻常型银屑病患者皮损皮肤中 Semaphorin-3A 表达降低

• 发表时间: 2011
• 作者: Kou K;Nakamura F;Aihara M;Chin H;Seto K;Takada S;Komori-yamaguchi J;Kambara T;Nagashima Y;Goshima Y;Ikezawa Z
• 通讯作者: Ikezawa Z

Correlation between Semaphorin3A expression and the itch intensity and severity in patients with psoriasis

Semaphorin3A表达与银屑病患者瘙痒强度及严重程度的相关性

• 发表时间: 2010
• 作者: Kou K;Nakamiura F;Aihara M;Seto K;Komori J;Kambara T;Nagashima Y.;Goshma Y;Ikezawa Z
• 通讯作者: Ikezawa Z

Oral administration of collagen trioeotide improves dryness and pruritus in the acetone-induced dry skin model

口服胶原三酸可改善丙酮诱导的干性皮肤模型中的干燥和瘙痒

• 发表时间: 2012
• 作者: Okawa T;Yamaguchi Y;Takada S;Sakai Y;Numata N;Nakamura F;Nagashima Y,Ikezawa Z;Aihara M
• 通讯作者: Aihara M

A probable role of interleukin-18(IL-18) in pathogenesis of atopic dermatitis (AD) from the quantitative analysis of IL-18 in horny layer of AD patients.

通过对 AD 患者角质层 IL-18 的定量分析，探讨白细胞介素 18 (IL-18) 在特应性皮炎 (AD) 发病机制中的可能作用。

• 发表时间: 2010
• 作者: Ikezawa Z;Inoue Y;Aihara M;Harada I;Komori J;Kirino M;Nagashima Y
• 通讯作者: Nagashima Y

Semaphorin3Aの経鼻投与がOVA

Semaphorin3A 的鼻腔给药是 OVA

• 发表时间: 2010
• 作者: 澤城晴名;中村史雄,相原道子;長嶋洋治,池澤善郎;五嶋良郎
• 通讯作者: 五嶋良郎