Intratumoral heterogeneity of radiotracer uptake on new-generation PET systems: association with biologic behavior and treatment response

在新一代PET系统中经常观察到肿瘤内放射性示踪剂摄取的异质性。我们开发了一种定量分析人类PET图像肿瘤内异质性的方法。淋巴瘤与胃肠道间质瘤或子宫颈与子宫内膜癌的比较显示，后者具有更大的异质性。食管癌和肺癌化疗前后肿瘤内异质性在治疗后发生改变。较差的治疗反应与前处理状态的肿瘤内异质性相关。

Intratumoral heterogeneity of radiotracer uptake is often observed on new-generation PET systems. We developed the method of quantitative analysis for intratumoral heterogeneity in human PET images. Comparison of lymphoma and gastrointestinal stromal tumor or of uterine cervical and endometrial cancer revealed the latter of each analysis showed greater heterogeneity. Intratumoral heterogeneity was demonstrated to change after treatment in the evaluation of esophageal cancer and lung cancer before and after chemotherapy. Greater intratumoral heterogeneity in the pretreatment status associated with poor treatment response.