Development of diagnostic strategy based on variation of tumormetabolism using nuclear medicine metabolic imaging

我们使用正电子发射断层扫描技术评估了肿瘤的代谢变化。我们的研究显示了不同的代谢模式，这些结果将有助于各种恶性肿瘤的诊断和治疗。根据肿瘤缩小的CT图像评估放疗和/或化疗的早期反应。肿瘤对FMISO的摄取与治疗后肿瘤缩小呈负相关。FMISO可能是一个很好的治疗预测指标。乳腺癌表现出不同的代谢模式，这可能与乳腺癌固有的亚型有关。

We evaluated a metabolic variation of tumors using positron emission tomography. Various metabolic patterns were demonstrated in our studies, and these results should be useful for diagnosis and therapy of various malignant tumors. An early response to radiation and/or chemotherapy was evaluated based on tumor shrinkage using CT images. The FMISO uptake in the tumor had a negative correlation with the tumor shrinkage after therapy. FMISO may be a good predictive indicator for therapy. Breast cancer showed various metabolic patterns, which may correlate with the intrinsic subtypes.