Radiotoxicity after Sr-89 therapy for bone metastasis using γ-H2AX Foci of DNA damage in lymphocytes

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The purpose of our study was to evaluate the degree of radiotoxicity to lymphocytes after strontium-89 therapy for bone metastases using γ-H2AX foci immunodetection. DNA damage to lymphocytes induced by Sr-89 in vivo should result in increased numbers of cells with nuclear foci stained by γ-H2AX. γ-H2AX foci immunodetection in lymphocytes may detect radiation-induced DNA damage associated with strontium-89 therapy for bone metastases, and may facilitate estimation of the radiation doses absorbed with thistherapy.