Chemotherapeutic enhancement of antitumor effect of Auger electrons-emitting antisense oligonucleotides on human neuroblastoma

俄歇电子发射反义寡核苷酸对人神经母细胞瘤的化疗增强抗肿瘤作用

• 批准号: 22591361
• 负责人: WATANABE Naoyuki
• 金额: $ 2.83万
• 依托单位: Gunma Prefectural College of Health Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591361/
• 关键词: 放射線科学; 分子生物学; アンチセンス; RI 内用療法; がん; 化学療法; RI内用療法; がん分子標的治療; RIアンチセンス療法; 最小侵襲治療法

Auger electrons are able to create breaks in mRNA (messenger ribonucleic acids), giving them possible therapeutic utility against malignant tumor. The antitumor effect of combined use of In-111-labeled N-myc antisense oligonucleotides and cis-diamminedichloroplatinum (II) (CDDP) was investigated in human neuroblastoma intraperitoneally transplanted to BALB/c athymic mice. The effects of In-111-labeled N-myc antisense oligonucleotides against human neuroblastoma cells and transplanted to athymic nude mice were found elsewhere. The response of the tumor to CDDP was relevant to the dose administered. Regression of the tumor was observed when CDDP was administered at about 5 mg/kg/injection. The retardation of tumor growth was observed in the group to which CDDP was administered at about 2 mg/kg/injection. When CDDP was administered with In-111-labeled N-myc antisense oligonucleotides, regression of the tumor was observed in the group treated with In-111-labeled N-myc antisense oligonuclotides, and the retardation of tumor growth was observed in the group treated with In-111-labeled N-myc antisense oligonucleotides at the lower doses. These results indicate that CDDP enhances the antitumor effect of In-111-labeled N-myc antisense oligonucleotides against transplanted neuroblastoma in BALB/c athymic mice.

俄歇电子能够在mRNA（信使核糖核酸）中产生断裂，使它们对恶性肿瘤具有可能的治疗效用。本文观察了~（111）In标记的N-myc反义寡核苷酸与顺铂（CDDP）联合应用对BALB/c裸鼠腹腔移植人神经母细胞瘤的抗肿瘤作用。In-111标记的N-myc反义寡核苷酸对人神经母细胞瘤细胞和移植到无胸腺裸鼠的作用在别处被发现。肿瘤对CDDP的反应与给药剂量有关。当以约5 mg/kg/注射施用CDDP时，观察到肿瘤消退。在以约2 mg/kg/注射施用CDDP的组中观察到肿瘤生长的延迟。当CDDP与In-111标记的N-myc反义寡核苷酸一起给药时，在用In-111标记的N-myc反义寡核苷酸治疗的组中观察到肿瘤消退，并且在用In-111标记的N-myc反义寡核苷酸以较低剂量治疗的组中观察到肿瘤生长的延迟。这些结果表明，CDDP增强In-111标记的N-myc反义寡核苷酸对BALB/c裸鼠移植性神经母细胞瘤的抗肿瘤作用。

项目成果

放射線とはどういうものですか？

什么是辐射？

• 发表时间: 2012
• 期刊: チャイルドヘルス
• 作者: Ju YI;Sone T;Kei Yamada;佐々木敏秋;尾藤良孝，河合裕子，平田宏司，恵飛須俊彦，大竹陽介，平田智嗣，白猪亨，五月女悦久，越智久晃，梅田雅宏，樋口敏宏，田中忠蔵;渡邉直行
• 通讯作者: 渡邉直行

Estimation of risk for the general public contaminated with radioiodine in nuclear accidents from the viewpoint of nuclear medicine physicians

从核医学医师的角度评估核事故中公众受到放射性碘污染的风险

• 发表时间: 2011
• 期刊: Radiation Protection Dosimetry
• 影响因子: 1
• 作者: N. Watanabe;K. Endo
• 通讯作者: K. Endo

原子力緊急事態における内部被ばく医療のためのRI 内用療法施設利用と仮設型内部被ばく患者治療施設の併設に係る提言

关于在核紧急情况下使用 RI 内治疗设施进行内辐射医疗和建立临时内辐射患者治疗设施的建议

• 发表时间: 2011
• 期刊: 核医学
• 作者: 渡邉直行;佐藤弘之;河原浩;佐々木康人
• 通讯作者: 佐々木康人

Imaging cancer therapeutic Trastuzumab bound on breast cancer cells with In-111-Biotin-Bn-EDTA-Anti-Human IgG1 monoclonal antibodies followed by the injection of macroaggregated albumin-avidin conjugate chase

使用 In-111-生物素-Bn-EDTA-抗人 IgG1 单克隆抗体对结合在乳腺癌细胞上的癌症治疗剂曲妥珠单抗进行成像，然后注射大聚集白蛋白-亲和素缀合物

• 发表时间: 2011
• 作者: N. Watanabe;K. Yoshizumi;S. Tanada;Y. Sasaki
• 通讯作者: Y. Sasaki

合同ワークショップ:核医学治療のあり方について

联合研讨会：关于核医学治疗的现状

• 发表时间: 2010
• 作者: 上田 怜;中塚豊真;稲葉忠司;他;曽根照喜,大成和寛;渡邉直行
• 通讯作者: 渡邉直行