The Effect of intra-vertebral injection of Bisphosphonate: An Experimental Study in an Osteoporotic Rabbit Lumbar Spine Model following Radiofrequency Ablation

椎内注射双膦酸盐的效果：射频消融后骨质疏松兔腰椎模型的实验研究

• 批准号: 22591367
• 负责人: NAKATSUKA Atsuhiro
• 金额: $ 2.5万
• 依托单位: Mie University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591367/
• 关键词: ラジオ波焼灼術・; 椎体形成術; 骨粗鬆症; マイクロCT・ビスフォスフォネート; radiofrequency ablation; rabbit spine model; bone strength; micro CT; bisphosphonate; intravertebral injection; osteoporosis; histopathology; rabbit lumber spine model; bisphosponate; osteporosis; r

Bone strength in ablated lumbar spines was significantly fragile as compared with control group due to bony microarchitectural destruction of the trabeculae. Both effects of intra-venous and intra-vertebral injection of Bisphosphonate were found to be similar in changing in both bone strength and bony micro-architecture.

由于骨小梁的骨微结构破坏，与对照组相比，被消融的腰椎的骨强度明显脆弱。研究发现，静脉内和椎体内注射双膦酸盐对骨强度和骨微结构的影响相似。

项目成果

Effect of Intra-venous Versus Intra-vertebral Injection of Bisphosphonate in an Rabbit Lumbar Spine Model weakened by Radiofrequency Ablation: Changes in Physical Properties and Micro CT-Histopathologic Correlation

静脉注射与椎内注射双膦酸盐对射频消融削弱的兔腰椎模型的影响：物理特性的变化和显微 CT 组织病理学相关性

• 发表时间: 2011
• 作者: Atsuhiro Nakatsuka;Koichiro Yamakado;Kan Takeda
• 通讯作者: Kan Takeda

兎の腰椎におけるRFA後のビスホスホネートの効果に関する実験的検討

RFA术后双磷酸盐对兔腰椎影响的实验研究

• 发表时间: 2013
• 作者: 中塚豊真;山門亨一郎
• 通讯作者: 山門亨一郎

増骨剤の治療効果に関する生体力学的評価

骨增稠剂治疗效果的生物力学评价

• 发表时间: 2011
• 期刊: 三重大学工学部修士論文集
• 作者: 上田 怜;中塚豊真;稲葉忠司
• 通讯作者: 稲葉忠司

Osteoporotic Rabbit Lumbar Spine Model following Radiofrequency Ablation; Evaluation of Physical Properties and Micro CTHistopathologicCorrelation

射频消融后骨质疏松兔腰椎模型；

• 发表时间: 2011
• 作者: Atsuhiro Nakatsuka;Koichiro Yamakado;Ray Ueda;Kan Takeda
• 通讯作者: Kan Takeda

Changes in Bone Structure and Strength following Radiofrequency Ablation with and without Vertebroplasty

射频消融术（有或没有椎体成形术）后骨结构和强度的变化

• 发表时间: 2013
• 期刊: an ex vivo Study in Swine Spine Journal of Biomedical Science and Engineering
• 作者: Atsuhiro Nakatsuka;Koichiro Yamakado
• 通讯作者: Koichiro Yamakado