X-ray angiography by intravascular generation of a large quantity of carbon dioxide microbubbles

我们设计了一种二氧化碳微泡对比度增强的方法，将生理盐水和二氧化碳气体混合在血管内，产生大量的微泡。血管内大量微泡的产生促进了辐射透明度，并可起到负对比剂的作用。由于微泡不会聚集在一起，而且它们的上升速度也非常慢，这使得在给定的液体体积内可以产生大量的微泡，并且产生气液两相流的可能性也较小。这项研究的目的是证明二氧化碳微泡造影剂在用于X射线诊断时可以显示血管。

We devised a method of CO2 microbubble contrast enhancement, whereby physiological saline and CO2 gas are mixed within blood vessels to generate a large quantity of microbubbles. The generation of a large quantity of microbubbles within blood vessels promotes radiolucency and can function as a negative contrast medium. As the microbubbles do not aggregate together, and their rate of ascent is also extremely slow, this enables a large amount of microbubbles to be generated within a given volume of liquid, and there is also less chance of generating a gas-liquid two-phase flow. The objective of this study was to demonstrate that CO2 microbubble contrast enhancement depicts blood vessels when used for X-ray diagnosis.