Preoperative chemo-radiation therapy for rectal cancer by analysis of chemo-radiation sensitizing gene expression

直肠癌术前放化疗治疗的放化疗增敏基因表达分析

• 批准号: 22591414
• 负责人: HOTTA Tsukasa
• 金额: $ 2.83万
• 依托单位: Wakayama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591414/
• 关键词: 外科総論; 直腸癌; 術前化学放射線療法

This study tried to demonstrate the effect of chemo-radiation therapy for 24 patients with rectal cancer including 13 high sensitive patients for chemo-radiation (high sensitive group) and 11 low sensitive patients for chemo-radiation (low sensitive group) as to analysis of chemo-radiation sensitizing gene expression. Twelve of 13 patients in high sensitive group resulted in down stage, whereas 10 of 11 patients in low sensitive group resulted in down stage. Eleven of 13 patients in high sensitive group resulted in group1 for colonoscopic biopsy after chemo-radiation, whereas 2 of 11 patients in low sensitive group resulted in group1. Four of 13 patients in high sensitive group resulted in histopathological complete cure in excised organ after surgery. There were extramural cancer deposits without lymph node structures in 2 of 13 patients in high sensitive group, whereas 7 of 11 patients in low sensitive group. It was not clear of the effect of chemo-radiation sensitizing gene expression.

本研究探讨24例直肠癌患者放化疗的疗效，包括13例放化疗高敏患者(高敏组)和11例放化疗低敏患者(低敏组)，分析放化疗增敏基因的表达。高敏感组13例中有12例出现下降期，而低敏组11例中有10例出现下降期。高敏组13例中有11例化疗后行结肠镜活检，低敏组11例中有2例在化疗后行结肠镜活检。高敏组13例中有4例术后切除脏器病理组织学完全治愈。高敏感组13例中有2例有无淋巴结结构的壁外癌沉积，而低敏感组11例中有7例有癌结膜外沉积。目前尚不清楚放化疗对基因表达的增敏作用。

项目成果

腹腔鏡補助下結腸切除術の学習効果と肥満

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• 发表时间: 2011
• 作者: Saito T;Saito T;Sato Y;Ise K;Anazawa T;Oshibe I;Haga J;Yamamoto M;Waguri S;Gotoh M.;堀田司
• 通讯作者: 堀田司

腹腔鏡補助下結腸切除術と腹腔鏡補助直腸切除術の学習効果

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• 发表时间: 2010
• 作者: Saito Takahiro;Ohasi K;Uto R;Shimizu H;Ise K;Suzuki H;Yamato M;Okano M Gotoh M;堀田司
• 通讯作者: 堀田司

直腸癌における側方郭清の限界と適応

直肠癌侧向清扫的局限性和适应症

• 发表时间: 2010
• 作者: 花山寛之,大橋一夫,鵜頭理恵;伊勢一哉,櫻井文教,水口裕之,岡野光夫,後藤満一;横山省三
• 通讯作者: 横山省三