Preoperative chemo-radiation therapy for rectal cancer by analysis of chemo-radiation sensitizing gene expression

点击翻译按钮获取中文摘要

This study tried to demonstrate the effect of chemo-radiation therapy for 24 patients with rectal cancer including 13 high sensitive patients for chemo-radiation (high sensitive group) and 11 low sensitive patients for chemo-radiation (low sensitive group) as to analysis of chemo-radiation sensitizing gene expression. Twelve of 13 patients in high sensitive group resulted in down stage, whereas 10 of 11 patients in low sensitive group resulted in down stage. Eleven of 13 patients in high sensitive group resulted in group1 for colonoscopic biopsy after chemo-radiation, whereas 2 of 11 patients in low sensitive group resulted in group1. Four of 13 patients in high sensitive group resulted in histopathological complete cure in excised organ after surgery. There were extramural cancer deposits without lymph node structures in 2 of 13 patients in high sensitive group, whereas 7 of 11 patients in low sensitive group. It was not clear of the effect of chemo-radiation sensitizing gene expression.