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The novel gene therapy using adeno-associated viral vector mediatedMDA7/IL-24 for human pancreatic cancer

The novel gene therapy using adeno-associated viral vector mediatedMDA7/IL-24 for human pancreatic cancer
使用腺相关病毒载体介导的MDA7/IL-24治疗人胰腺癌的新型基因疗法
批准号:
22591444
负责人:
AIMOTO Takayuki
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
We established a orthotropic pancreatic cancer model in hamsters using the pancreatic cancer cell line, PGHAM-1 and generated adeno-associated viral vector expressing MDA7/IL-24. The survival time both in the gene therapy alone and in the gene therapy plus gemcitabine group was longer than that in the control group. There were no detectable side effects. This novel gene therapy is a potentially effective treatment for pancreatic cancer although further studies are needed in the near future.
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会议论文
Time-dependent changes in endoscopic findings of intestine in patient with acute superior mesenteric arterial thrombosis after pancreaticoduodenectomy.
胰十二指肠切除术后急性肠系膜上动脉血栓形成患者肠道内镜检查结果随时间的变化。
DOI: --
发表时间: 2012
期刊: Dig Endosc.
影响因子: --
作者: [Mizutani S, Suzuki H, Aimoto T]
通讯作者: Aimoto T
The effect and specific mechanisms of systemic gene therapy using AAV8-IL24 in MLL/AF4 Tg mice
AAV8-IL24对MLL/AF4 Tg小鼠全身基因治疗的效果及具体机制
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Tamai, H.]
通讯作者: H.
Establishment and Characterization of A New Lymphoid Malignancy Mouse Model Induced by the combination of MLL/AF4 and K-RAS.
MLL/AF4 和 K-RAS 联合诱导的新型淋巴恶性肿瘤小鼠模型的建立和表征。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Tamai, H.]
通讯作者: H.
DOI: 10.1038/leu.2011.104
发表时间: 2011-09
期刊: Leukemia
影响因子: 11.4
作者: [S. Wakita;H. Yamaguchi;Koichi Miyake;Y. Mitamura;F. Kosaka;Kazuo Dan;K. Inokuchi]
通讯作者: S. Wakita;H. Yamaguchi;Koichi Miyake;Y. Mitamura;F. Kosaka;Kazuo Dan;K. Inokuchi
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