The study of the mechanism of Wnt signal in the gastric cancer stem cell and the application to the cancer therapy.
The study of the mechanism of Wnt signal in the gastric cancer stem cell and the application to the cancer therapy.
批准号:
22591453
负责人:
TANABE Kazuaki
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
This study was originally planned to comfirm the specific marker for gastric cancer stem cell. In the study, we found that CD24 is one of factor of malignant potential in gastric cancer. Up-regulation of CD24 results the up-regulation of both adhesion and invasion. Furthermore, CD24 is more expressed under hypoxic condition compare to normoxia. We found that HIFs take apart in the induction of the CD24 expression. CD24 plays important rolls in gastric cancer invasion.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Hypoxia induces expression of CD24
缺氧诱导 CD24 表达
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Fujikuni Noriaki, Tanabe Kazuaki]
通讯作者:
Tanabe Kazuaki
A new methods for intraluminal gastrointestinal stromal tumor resection using laparoscopic seromuscular dissection technique.
腹腔镜浆肌解剖技术腔内胃肠道间质瘤切除的新方法。
DOI:
--
发表时间:
2011
期刊:
Digestive Surgery
影响因子:
2.7
作者:
[Mizutani S, Suzuki H, Aimoto T, Kazuaki Tanabe]
通讯作者:
Kazuaki Tanabe
Hypoxia induces expression of CD24: an invasion stimulation factor of gastric cancer cells
缺氧诱导胃癌细胞侵袭刺激因子CD24的表达
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Miyazaki T, Tanaka N, Hirai H, Yokobori T, Sano A, Sakai M, Inose T, Sohda M, Nakajima M, Fukuchi M, Kato H, Kuwano H, Takanori Maruyama, 藤國宣明(田邊和照)]
通讯作者:
藤國宣明(田邊和照)
Therapeutic aplication to gastric cancer by CD24 expression control
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批准号:25462023
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.16万
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财政年份:2013
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负责人:TANABE Kazuaki
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依托单位:
海外基金