Development of the systems in early detection and prediction of chemo and/or radiation sensitivity for digestive tract cancers using a novel cancer-associated gene, SMYD2

我们研究了癌症相关基因SMYD2过表达在消化道癌症化疗和/或放疗敏感性中的意义。然而，直到现在，我们还没有得到表明这种关联的日期。然而，我们证明了使用血浆DNA及其血浆SMYD2/RUNX3比值在食管鳞状细胞癌中的癌症检测和预后预测的临床影响。此外，我们证明了SMYD2的过表达与肝癌细胞系的肿瘤进展有关。此外，SMYD2蛋白的高表达与Vater乳头癌患者的静脉侵犯和较差的预后有关。我们将继续研究SMYD2的详细分子机制，并在不久的将来报道。

We investigated the significance of cancer-related gene, SMYD2 overexpression in the chemo and/or radiation sensitivity for digestive cancers. However, until now, we have notyet obtained the date to indicate the association. Whereas, we demonstrated that clinical impact of cancer detection and prognostic prediction using plasma DNA and its plasma SMYD2/RUNX3 ratio in esophageal squamous cell carcinoma. Furthermore, we proved that overexpression of SMYD2 is related to tumor progression in hepatocelluler carcinomacell lines. Also, higher expression of SMYD2 protein is associated with venous invasion and poorer prognosis in patients with carcinoma of the papilla of Vater . We will continue to examine the detail molecular mechanism of SMYD2 and report them in near future.