Development of the systems in early detection and prediction of chemo and/or radiation sensitivity for digestive tract cancers using a novel cancer-associated gene, SMYD2

使用新型癌症相关基因 SMYD2 开发早期检测和预测消化道癌症化疗和/或放射敏感性的系统

• 批准号: 22591465
• 负责人: SONOYAMA Teruhisa
• 金额: $ 2.83万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591465/
• 关键词: 癌遺伝子; SMYD2; 消化器外科学

We investigated the significance of cancer-related gene, SMYD2 overexpression in the chemo and/or radiation sensitivity for digestive cancers. However, until now, we have notyet obtained the date to indicate the association. Whereas, we demonstrated that clinical impact of cancer detection and prognostic prediction using plasma DNA and its plasma SMYD2/RUNX3 ratio in esophageal squamous cell carcinoma. Furthermore, we proved that overexpression of SMYD2 is related to tumor progression in hepatocelluler carcinomacell lines. Also, higher expression of SMYD2 protein is associated with venous invasion and poorer prognosis in patients with carcinoma of the papilla of Vater . We will continue to examine the detail molecular mechanism of SMYD2 and report them in near future.

我们研究了癌症相关基因SMYD 2过表达在消化道肿瘤化疗和/或放疗敏感性中的意义。然而，到目前为止，我们还没有得到表明这种关联的日期。然而，我们证明了在食管鳞状细胞癌中使用血浆DNA及其血浆SMYD 2/RUNX 3比率进行癌症检测和预后预测的临床影响。此外，我们证明SMYD 2的过表达与肝细胞癌细胞系中的肿瘤进展有关。此外，SMYD 2蛋白的高表达与Vater乳头癌患者的静脉浸润和预后不良相关。我们将继续研究SMYD 2的详细分子机制，并在不久的将来报道它们。

项目成果

Optimal surgical treatment for patients with pT2 gallbladder cancer

pT2胆囊癌患者的最佳手术治疗

• 发表时间: 2011
• 期刊: Hepatogastroenterology
• 作者: K. Harada;T. Sonoyama;T. Ochiai,S. Komatsu;E. Otsuji;et al.
• 通讯作者: et al.

Intraoperative real-time cholangiography and C-tube drainage in donor hepatectomy reduce biliary tract complications

供肝切除术中实时胆道造影和 C 管引流可减少胆道并发症

• DOI: 10.1007/s11605-011-1681-9
• 发表时间: 2011
• 期刊: J Gastrointest Surg
• 影响因子: 3.2
• 作者: Ochiai T;Sonoyama T;et al
• 通讯作者: et al

A case involving long-term survival after esophageal cancer with liver and lung metastases treated by multidisciplinary therapy: report of a case

• DOI: 10.1007/s00595-012-0240-7
• 发表时间: 2013-05-01
• 期刊: SURGERY TODAY
• 影响因子: 2.5
• 作者: Iitaka, Daisuke;Shiozaki, Atsushi;Otsuji, Eigo
• 通讯作者: Otsuji, Eigo

A case of a superficial carcinoma of the esophagus with isolated lymph node metastasis around the abdominal aorta.

浅表性食管癌伴腹主动脉周围孤立性淋巴结转移一例。

• DOI: 10.1007/s00595-012-0148-2
• 发表时间: 2012
• 期刊: Surgery Today
• 影响因子: 2.5
• 作者: Hatakeyama T;Shiozaki A;Kokuba Y;Otsuji E;et al.
• 通讯作者: et al.

Prognostic impact of histological blood vessel invasion in patients with ampullary adenocarcinoma.

壶腹腺癌患者组织学血管侵犯的预后影响。

• 发表时间: 2010
• 期刊: Hepatogastroenterology
• 作者: Kawaguchi T;Sonoyama T;et al
• 通讯作者: et al