Development of the systems in early detection and prediction of chemo and/or radiation sensitivity for digestive tract cancers using a novel cancer-associated gene, SMYD2

我们研究了肿瘤相关基因SMYD2过表达在消化系肿瘤化疗和/或放射敏感性中的意义。然而，到目前为止，我们还没有得到表明这种联系的日期。然而，我们证明了利用血浆DNA及其SMYD2/RUNX3比值对食管鳞癌进行肿瘤检测和预后预测的临床意义。此外，我们还证实了SMYD2的过表达与肝癌细胞系的肿瘤进展有关。此外，SMYD2蛋白的高表达与Vater乳头癌患者的静脉侵犯和预后不良有关。我们将继续研究SMYD2的详细分子机制，并在不久的将来报道它们。

We investigated the significance of cancer-related gene, SMYD2 overexpression in the chemo and/or radiation sensitivity for digestive cancers. However, until now, we have notyet obtained the date to indicate the association. Whereas, we demonstrated that clinical impact of cancer detection and prognostic prediction using plasma DNA and its plasma SMYD2/RUNX3 ratio in esophageal squamous cell carcinoma. Furthermore, we proved that overexpression of SMYD2 is related to tumor progression in hepatocelluler carcinomacell lines. Also, higher expression of SMYD2 protein is associated with venous invasion and poorer prognosis in patients with carcinoma of the papilla of Vater . We will continue to examine the detail molecular mechanism of SMYD2 and report them in near future.