Analysis of immunity induction in rectal cancer in association with microscopic abscess formation

点击翻译按钮获取中文摘要

We investigated gene profile between MAF positive and negative cancer. Eleven genes including Toll-like receptor 7 (TLR7) were overexpressed in MAF positive cancer. We focused on myeloid differentiation factor 88 (MyD88), the downstream component of TLR7. RT-PCR demonstrated that MyD88 was downregulated in MAF positive cancer, compared with MAF negative cancer. Our data indicated that lower expression of MyD88 is related with their better prognosis in MAF positive cancer. Interestingly, nevertheless MyD88 expression is mediated by TLR7, the discrepancy exists between expression of TLR7 and MyD88 in MAF positive cancer. We estimate that other genes except TLR7 regulate MyD88 expression in MAF positive cancer.